My uncle (NOT an MD) used to work for Pfizer (retired for about a decade), doing computer analysis of their various Drug trial data, here is what he had to say on the vaccine data…
More thoughts on the Pfizer mRNA vaccine:
One of my Pfizer contacts sent me a link to an article in the New England Journal of Medicine. Since it has been published, there is no reason not to share it with my friends:
The article is written for professionals and it is pretty jargon rich. You may not choose to wade through it. There are several points, however, that can be made in plain English
1. This stuff is DAMN GOOD!
The news stories about effectiveness greater than 90% appear to be accurate at least over the 119 days of the clinical trial. The research protocol aimed for 50% protection (the efficacy standard demanded by the CDC.) Pfizer blew that out of the water. The study covered over 43000 subjects and fewer than one in 1000 developed covid-19 symptoms (only 1 was severe.)
2. It works better and faster than expected.
The study called for one dose at day 0 and one at day 21. The treatment group departed from the placebo group at day 11 and never looked back.
3. One dose APPEARS to give significant protection.
It is not clear how long the protection would last without the ‘booster’ shot, but the protection before the second dose is significant.
Figure 3 tells the tale. You rarely see plots like that in real-world data analysis.